Prader-Willi syndrome (PWS) is a genetic disorder characterized by impairment of a myriad of physiological systems including growth, development, metabolism and reproduction. Although the physiological deficits observed in individuals with PWS come to be well-recognized, the mechanisms and/or cause for the generation of these characteristics are not fully understood. One feature common to patients diagnosed with PWS is the high levels of circulating hormone ghrelin. Ghrelin is produced predominantly by the stomach cells.
Institution:
University of Texas Southwestern Medical Center
