Growth hormone and sleep

Growth, Genetics, and Hormones is a free e-newsletter, primarily for endocrinologists (but anyone can sign up and receive it). One very nice feature they have is a review of recent articles of interest in the literature, with editorial comments about the implications of the studies.

 Here : they review a recent article by Dr. Miller regarding the initiation of growth hormone therapy and sleep in PWS. (Miller J, Silverstein J, Shuster J, Driscoll DJ, Wagner M. Short-term effects of growth hormone on sleep abnormalities in Prader-Willi Syndrome. J Clin Endocrinol Metab. 2005; epub (10.1210/jc.2005-1279).

That paper looked at the changes in sleep in the 6 weeks following initiation of GH therapy. Most patients had better sleep (less apnea), and this is consistent with longer term studies that show improvements in sleep quality. However, about a third had worsening of sleep disturbances – generally associated with enlarged tonsils and upper respiratory infections. They recommended sleep studies at baseline and 6 weeks after initiating GH therapy in patients with PWS. GGH comments on their findings.

Topics: Research

Theresa Strong


Theresa V. Strong, Ph.D., received a B.S. from Rutgers University and a Ph.D. in Medical Genetics from the University of Alabama at Birmingham (UAB). After postdoctoral studies with Dr. Francis Collins at the University of Michigan, she joined the UAB faculty, leading a research lab focused on gene therapy for cancer and directing UAB’s Vector Production Facility. Theresa is one of the founding members of FPWR and has directed FPWR’s grant program since its inception. In 2016, she transitioned to a full-time position as Director of Research Programs at FPWR. She remains an Adjunct Professor in the Department of Genetics at UAB. She and her husband Jim have four children, including a son with PWS.

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