Obsessive-compulsive symptoms among youth with Prader-Willi Syndrome (PWS) are frequently present and associated with considerable problems in the daily functioning of the child and his/her family. Although pharmacological and psychosocial treatments exist that target obsessive-compulsive symptoms among typically developing youth, these treatments have not been systematically adapted and/or evaluated for this population. Furthermore, although psychotropic medications have shown promising support in addressing obsessive-compulsive symptoms in several case reports involving youth with PWS, associated efficacy is modest and potential for side effects is a realistic concern. Given efficacy and tolerability of cognitive-behavioral treatment for obsessive-compulsive symptoms in typically developing youth, an adapted version of this approach may hold promise in treating clinically problematic obsessive-compulsive symptoms in youth with PWS. Thus, we report on a case series of behavioral treatment for obsessive-compulsive symptoms in three youth with PWS. Diagnostic and symptom severity assessments were conducted at screening, pre-treatment, and post-treatment by a trained independent evaluator. All youth were considered treatment responders and exhibited meaningful reductions in compulsion severity, overall obsessivecompulsive severity, and obsessive-compulsive related impairment. These data provide preliminary evidence for the utility of behavioral therapy in treating obsessive-compulsive symptoms in youth with PWS.
The mission of FPWR is to eliminate the challenges of Prader-Willi syndrome through the advancement of research. High-quality research will lead to more effective treatments and an eventual cure for this disorder. By working together, we intend to free our loved ones from the burdens of PWS, allowing them to lead full and independent lives.
Foundation for Prader-Willi Research Phone: 888-322-5487 Fax: 888-559-4105 Email: firstname.lastname@example.org