The gut microbiome in Prader-Willi syndrome
Funding Summary
Dr. Costa-Mattioli has shown that the composition of the gut microbiome can influence autistic behaviors in mouse models, and that this influence acts through the oxytocin system. This study will examine Magel2-deficient mice and will focus on determining whether altering the gut microbiome can impact social behaviors.
Lay Abstract
Prader-Willi syndrome individuals show impaired social behaviors and altered oxytocin levels in the brain, but the reason for this remains unknown. Here we will test whether changes in the gut bacterial content in PWS could perturb social behaviors and related changes in oxytocin. In addition, we will examine whether a probiotic bacteria strain that promotes reverses social behaviors in a mouse model of PWS.
Research Outcome
Our findings, using two mouse models, show that Magel2 KO mice did not exhibit social behavioral deficits.
Funded Year:
2018
Awarded to:
Mauro Costa-Mattioli, Ph.D.
Amount:
$108,000
Institution:
Baylor College of Medicine
Researcher:
