Projects Archive - Foundation for Prader-Willi Research | Organoids/Assembloids

Under the guidance of our Scientific Advisory Board through a carefully managed grants process, FPWR selects research projects based on the collaborative input of researchers and parents, choosing projects that are both scientifically meritorious and highly relevant for individuals with PWS and their families.

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Deciphering the molecular mechanisms of neuronal development deficits in Prader-Willi syndrome: insights into hypothalamic dysfunction

Funded Year: 2025

By creating three-dimensional hypothalamic organoids from hiPSCs with PWS-relevant deletions, Dr. Tai will investigate how specific genetic changes drive molecular and cellular alterations in PWS. The study will identify disease-relevant genes, pathways, and cell types, establishing a framework for future research that includes rescuing molecular...

Disentangling developmental and hormone responsive dysfunction of human hypothalamic circuits in Prader-Willi Syndrome

Funded Year: 2025

The focus of our proposal is to unravel the complexities of developmental and hormone-responsive dysfunction within human hypothalamic circuits in Prader-Willi Syndrome using cutting edge human brain circuits within a petri dish using organoids.

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About FPWR

The Foundation for Prader-Willi Research (federal tax id 31-1763110) is a nonprofit corporation with federal tax exempt status as a public charity under section 501(c)(3).

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The mission of FPWR is to eliminate the challenges of Prader-Willi syndrome through the advancement of research and therapeutic development.

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Foundation for Prader-Willi Research
Phone: 888-322-5487
Email: info@fpwr.org

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