Deciphering the molecular mechanisms of neuronal development deficits in Prader-Willi syndrome: insights into hypothalamic dysfunction
Funded Year: 2025By creating three-dimensional hypothalamic organoids from hiPSCs with PWS-relevant deletions, Dr. Tai will investigate how specific genetic changes drive molecular and cellular alterations in PWS. The study will identify disease-relevant genes, pathways, and cell types, establishing a framework for future research that includes rescuing molecular...