Prader-Willi Syndrome Macronutrient Study

The overall objective of this FPWR funded study is to explore the mechanisms by which macronutrients regulate hyperphagia, satiety, food intake and weight gain in Prader Willi Syndrome (PWS). Using  a cutting edge metabolomics approach, researchers will measure a broad array of hormones, cytokines, amino acids and fatty acid metabolites prior to and 48 hours after either a low carbohydrate or low fat diet. The study will also ask whether a low carbohydrate diet suppresses levels of the hunger hormone ghrelin and increases appetite-suppressing hormones to a greater degree and for longer duration than a low fat diet.  Information obtained from this study will be used to design evidence-based diet plans for children with PWS.

There are (2) study site locations at Duke University and at the University of Alberta.

For more details on inclusion/exclusion criteria and study specifics, please visit the clinicaltrials page here. For additional information, please contact one of the study coordinators listed below:

  1. Krystal A Irizarry, MD, (919) 684-8250,
  2. Michael Freemark, MD, (919) 684-8350,
  3. Andrea M Haqq, MD, (780) 492-0015,
Tools for PWS Awareness

Volunteer Your Time

No matter how big or how small, every effort helps us!