Projects Archive - Foundation for Prader-Willi Research | metabolics

Under the guidance of our Scientific Advisory Board through a carefully managed grants process, FPWR selects research projects based on the collaborative input of researchers and parents, choosing projects that are both scientifically meritorious and highly relevant for individuals with PWS and their families.

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Integration of Serum Metabolome and Gut Microbiome to Identify Host-Microbe Metabolic Interactions in PWS

Funded Year: 2023

This project will explore how the gut microbiome influences metabolic health in PWS. Dr. Haqq is collaborating with one of the world’s leading metabolomics lab (Dr. David Wishart) to characterize ‘metabolite’ profiles in children and adolescents with PWS and explore the links between blood metabolites, the gut microbe, and metabolic health in...

Role of Microbial Metabolites in Regulating Hypothalamic Pathways Involved in Feeding Behavior

Funded Year: 2023

The probiotic supplement, BPL1, shows promise improving metabolism and behavior in people with PWS, but more work is needed to understand how this gut microbiome intervention can be optimized. This project aims to understand how probiotic supplementation improves metabolic and mental health in individuals with PWS by influencing brain circuits...

Role of fat sensing in the altered feeding behavior and metabolic phenotype of Prader-Willi syndrome

Funded Year: 2022

Our project aims to test the hypothesis that alterations in certain specific lipid sensors and mediators in the hypothalamus may contribute to the disrupted feeding behavior and the altered metabolic phenotype associated with PWS at different stages of postnatal development. These studies will try to reverse the metabolic alterations observed...

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