We all wish, hope and work for a ‘cure’ for PWS - new treatments for the hunger, a new therapy to improve behavior, interventions to make our child’s life healthier, happier and more independent. After years with very few new drugs and interventions to test in PWS, we are about to embark on an important new period of PWS research.
All individuals with PWS have a set of normal genes on their maternally-derived chromosome, but the genes in the PWS regions are ‘silent’. Dr. Jiang will screen a library of 10,000 small molecules to identify candidate drugs that can reactivate the PWS region genes on the maternal chromosome 15, specifically SNRPN and snoRNAs. Promising candidate molecules will be tested for efficacy in PWS models, with the goal of ultimately evaluating their effects in patients. FPWR is asking the community to support Dr. Jiang’s work to identify candidate drugs for PWS. Contributions towards this study may be made through our Puzzle Project at puzzle.fpwr.org. Your $500 donation is tax deductible and will go directly towards the screening of candidate drugs for the use in Prader-Willi syndrome.
Share this opportunity with your family and friends! Download the
2014 Puzzle Project Support Request and donation form. For Canadian Donors, please visit
http://www.fpwr.ca/donate/ to make your puzzle donation. You will enter FPWR Canada's Pay Pal site where you may designate your donation to the 2014 Puzzle Project and a puzzle piece will be reserved for you.