Study Purpose GLWL is conducting a Phase 2 clinical trial to to evaluate the efficacy, safety, and pharmacokinetics of GLWL-01 in treating hyperphagia in patients with PWS. Participants will be assigned to one of two treatment sequences (GLWL-01/Placebo or Placebo/GLWL-01), with each sequence consisting of two treatment periods separated by a washout period.
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Researchers at Vrije University in Amsterdam are conducting a study to better understand how individuals with PWS perceive and feel pain. For more information, please see the recruitment flyer for the Pain Questionnaire study and contact postdocteam.fgb@vu.nl.
In this study, adults will be interviewed 3 times over a 6 month period will be asked questions about personal and family health, family history and routines and what everyday living is like caring for a child with PWS.
The purpose of this study is to determine the presence of central adrenal insufficiency in children with Prader Willi Syndrome using low dose (1 mcg) ACTH stimulation test compared to results of overnight metyrapone test. The study is being conducted at Nationwide Children's Hospital in Columbus, Ohio. For more information, visit clinicaltrials.gov here or contact the study coordinator.
NO LONGER RECRUITING
Update: This Phase I study has been completed - we look forward to publication of the results, and the next steps of oxytocin development.
There is limited research that has interviewed siblings to get an in-depth perspective of what it is/was like for them to live with a brother or sister with Prader-Willi Syndrome. Further research will allow for siblings to be better-understood and provided with adequate resources and support that they may not be currently receiving.
The overall objective of this FPWR funded study is to explore the mechanisms by which macronutrients regulate hyperphagia, satiety, food intake and weight gain in Prader Willi Syndrome (PWS). Using a cutting edge metabolomics approach, researchers will measure a broad array of hormones, cytokines, amino acids and fatty acid metabolites prior to and 48 hours after either a low carbohydrate or low fat diet. The study will also ask whether a low carbohydrate diet suppresses levels of the hunger hormone ghrelin and increases appetite-suppressing hormones to a greater degree and for longer duration than a low fat diet. Information obtained from this study will be used to design evidence-based diet plans for children with PWS.
