Research Publications Archive - Foundation for Prader-Willi Research | Learning Disabilities

Autism spectrum disorder in Prader-Willi syndrome: A systematic review

Prader-Willi syndrome (PWS) is a rare genetic disorder that results from lack of expression of paternally-derived genes on chromosome 15q11-13; caused by a deletion (DEL), uniparental disomy (UPD), or a rare imprinting center defect. PWS is associated with a distinct behavioral phenotype that in...

Reduced cortical complexity in children with Prader-Willi syndrome and its association with cognitive impairment and developmental delay

BACKGROUND: Prader-Willi Syndrome (PWS) is a complex neurogenetic disorder with symptoms involving not only hypothalamic, but also a global, central nervous system dysfunction. Previously, qualitative studies reported polymicrogyria in adults with PWS. However, there have been no quantitative...