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Developing Oligonucleotides To Rescue Missing SNORD115 In PWS [VIDEO]

This video with Dr. Stefan Stamm describes how SNORD115, missing in PWS, regulates expression the serotonin 2C receptor, involved in controlling appetite.

Dr. Stefan Stamm has been actively involved in the PWS research community for a number of years. His group has received FPWR funding to explore the complex biology of SNORD115 and SNORD116 in PWS, as well as pursue ways to rescue the function of these RNAs that are missing in individuals with PWS.

The University of Kentucky recently made a video highlighting his work and a recent publication titled "Oligonucleotide‐induced alternative splicing of serotonin 2C receptor reduces food intake." The video, embedded below, describes how SNORD115, which is missing in PWS, is normally involved in regulating expression of a protein called the serotonin 2C receptor. This receptor is one of many involved in controlling appetite. Dr Stamm's group is developing oligonucleotide mimics to substitute for the missing SNORD115 and restore regulation of the serotonin receptor. They have shown that this mimic reduces appetite in mice and are working toward the next steps to translate these results into a new approach of therapeutic development for PWS.


 Video by University of Kentucky Research Communications

 Understanding PWS - Slide Deck

Topics: Research

Jessica Bohonowych


Jessica Bohonowych is a graduate of Duke University, and holds a PhD in Pharmacology and Toxicology at the University of California, Davis. Incorporating her research background, knowledge of pharmacology and drug development, and teaching experience, Jessica works with Theresa Strong in managing FPWR’s grant portfolio, communicating research results and breakthroughs to our community, aiding in special projects such as the Clinical Trials Initiative and Molecular Resource Center, and is heading the development of the Global PWS Registry.