Have you ever wondered what is the optimal diet for a person with PWS? We may not be able to answer that question just yet, but in this 29-minute video, Dr. Anne Scheimann from Johns Hopkins shares preliminary data from her study on the Modified Atkins Diet (MAD) for PWS and on important changes it may have in the microbiome. They review diet strategies for PWS, go over the specifics of the MAD study, and share results related to weight changes and the microbiome. If you're short on time, scroll down for time stamps to find the portions you're most interested in.
Presentation Sections With Timestamps
00:28 Background: What is PWS?
00:47 Diet Strategies in PWS - example
01:38 Rationale for Consideration of Ketogenic Diets in PWS
03:00 Diet Comparison: Modified Atkins, Ketogenic and Standard Diets
03:47 Sample Modified Atkins Diet
04:30 Diet Study Design (funded by FPWR)
04:50 Methods, Inclusion/Exclusion Criteria
06:00 Study Patient Demographics
06:19 Study Results
- Weight was maintained or reduced during diet.
- Cholesterol increased, LDL increased
- Triglycerides were stable
- Hemoglobin A1C stable
- Insulin decreased
07:25 Microbiome Study
08:11 Why is the microbiome important?
08:52 Microbiome and Obesity
09:31 Microbiome and Behavior
10:10 Modified Atkins Diet in PWS – Microbiome Analyses
11:00 Microbiome Analyses – Pre and Post Diet with Parent Comparison Data
- A small numbers of patients participated in the study, however weight maintenance/loss was observed for the majority of patients. A shift in lipid profile and improvement in insulin resistance was also observed. While an impact upon gut microbiome was observed, it not yet known if this is beneficial or not.