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FPWR Blog

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Obestatin is not elevated in PWS

An article published last year described a new appetite suppressing peptide hormone, obestatin (see previous blog and reference here). One interesting feature about this peptide is that it appears to be derived from the same precursor as ghrelin, the...
October 30, 2006 Read More

Topics: Research

Ghrelin in young kids with PWS- waiting for the storm?

A new paper out in the Journal of Pediatrics looks at Ghrelin levels in young children with Prader-Willi syndrome - Erdie-Lalena CR, Holm VA, Kelly PC, Frayo RS, Cummings DE. J Pediatrics, 149:199-204, 2006). This study adds to the existing literatur...
September 19, 2006 Read More

Topics: Research

Review of Growth Hormone and PWS Mortality

Dr. Phillip Lee is an expert on PWS endocrine issues; notably growth hormone therapy in PWS. He wrote a review on the subject in the Growth, Genetics & Hormones journal, an online resource directed to endocrinologists and health professionals tha...
September 11, 2006 Read More

Topics: Research

Understanding how a weight loss drug works: serotonin linked to MC4R

Some years ago, the dietary pill Fen-Phen was a fairly widely used, effective drug for weight loss, and was even reported to be helpful in PWS in a small clinical trial: Selikowitz M, et al. Unfortunately, its adverse effects on the heart and lungs l...
August 13, 2006 Read More

Topics: Research

Portion size

Here's an article of interest from WebMD: Do Bigger Portions Lead to Bigger Kids? http://aolsvc.health.webmd.aol.com/content/Article/107/108575.htm
July 7, 2006 Read More

Topics: Research

Neuropeptide "S"

The International Congress of Neuroendocrinology was held this week at Univ Pittsburgh- some very interesting things were dicussed there .
June 23, 2006 Read More

Topics: Research

Modafinil and appetite

Modafinil (Provigil) has been suggested as a potential wake-promoting drug that might be helpful in PWS. Interestingly, this article (although a very small study) showed that individuals taking modafinil consumed less food.
June 16, 2006 Read More

Topics: Research

Genetics and behavior

Two new articles that just arrived in the new issue of the American Journal of Human Genetics caught my eye. Both articles deal with the serotonin system, and common genetic variants of the components of the system.
May 26, 2006 Read More

Topics: Research

Altering gene expression

Here's a very interesting summary of a research article just published in the journal Cell. The important point here (at least for the sake of this conversation) is not the prostate cancer link - but rather the identification of another protein that ...
May 5, 2006 Read More

Topics: Research

About FPWR

The Foundation for Prader-Willi Research (federal tax id 31-1763110) is a nonprofit corporation with federal tax exempt status as a public charity under section 501(c)(3).

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The mission of FPWR is to eliminate the challenges of Prader-Willi syndrome through the advancement of research and therapeutic development.

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