Foundation for Prader-Willi Blog (78)

Increased number of ghrelin producing cells in PWS

Here is an article in which the authors investigated why people with PWS have high levels of ghrelin in their blood. They wondered if perhaps it had something to do with growth hormone (GH) deficiency, which is common in PWS.

July 9, 2005 Read More

Topics: Research

Comprehensive review of feeding regulation / obesity

Nature Neuroscience is a top notch science journal and this month they have a feature: "Feeding Regulation and Obesity". This 'focus' includes several comprehensive (and pretty hard-core science) reviews on the current understanding of the neurobiolo...

April 30, 2005 Read More

Topics: Research

Obesity drug development - link

Here's a nice summary of (some of the) ongoing obesity drug development strategies:

April 26, 2005 Read More

Topics: Research

New approach to gene therapy - zinc fingers

I wanted to share a new article that just came out in "Nature" (a very well respected journal) in the field of gene therapy. The link to the abstract is below. This advance is not likely to have an impact in PWS in the near future, but it does repres...

April 19, 2005 Read More

Topics: Research

Ghrelin in PWS and 'hypothalamic obesity'

Two recent papers look at the obesity due to hypothalamic damage (hypothalamic obesity-HO, which can occur, for example, after treatment for a brain tumor), and one directly compares that condition to PWS.

March 21, 2005 Read More

Topics: Research

Figuring out how C75 acts

Here's a new article trying to sort out how C75 acts. For those of you who have tried to read any of the medical literature on appetite/feeding/satiety, you have probably realized that there are many hormones and neurotransmitters that influence food...

March 20, 2005 Read More

Topics: Research

Orexin and addiction

Here is an interesting new study about orexin (aka hypocretin). Recall that orexin was first identified as an appetite stimulating molecule. It was then tied to narcolepsy (through stuides of a well-defined colony of narcoleptic dogs). It is involved...

February 16, 2005 Read More

Topics: Research

Another peptide that regulates appetite-neuromedin U

OK, you've learned about leptin and ghrelin (and maybe NPY, MSH, AgRP and CART). Here's another neuropeptide, neuormedin U, that is important in regulating body weight and energy expenditure.

November 9, 2004 Read More

Topics: Research

Pacemaker neurons integrate hunger and satiety

A paper supported by your funds has just come out. This study is from Dr. Spanswick, whose project: "Understanding the action of ghrelin in the brain: Identification of novel treatments for hyperphagia" FPWR is supporting.

May 27, 2004 Read More

Topics: Research

FPWR Blog

Categories

Increased number of ghrelin producing cells in PWS

Comprehensive review of feeding regulation / obesity

Obesity drug development - link

New approach to gene therapy - zinc fingers

Ghrelin in PWS and 'hypothalamic obesity'

Figuring out how C75 acts

Orexin and addiction

Another peptide that regulates appetite-neuromedin U

Pacemaker neurons integrate hunger and satiety

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