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with a request body that specifies how to map the columns of your import file to the associated CRM properties in HubSpot.... In the request JSON, define the import file details, including mapping the spreadsheet's columns to HubSpot data. Your request JSON should include the following fields:... entry for each column.

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Deletion vs. UPD: 70/30 or 50/50?

November 21, 2006

Most information about PWS starts out with a brief overview of the genetics of the condition. Deletion of chromosome 15 is listed as the most common cause of PWS, accounting for roughly 70% of cases. Maternal Uniparental Disomy (UPD), in

Obestatin is not elevated in PWS

October 30, 2006

An article published last year described a new appetite suppressing peptide hormone, obestatin (see previous blog and reference here). One interesting feature about this peptide is that it appears to be derived from the same precursor as ghrelin, the hunger

Understanding how a weight loss drug works: serotonin linked to MC4R

August 13, 2006

Some years ago, the dietary pill Fen-Phen was a fairly widely used, effective drug for weight loss, and was even reported to be helpful in PWS in a small clinical trial: Selikowitz M, et al. Unfortunately, its adverse effects on

Role for CPT-1 in weight regulation

May 1, 2006

A new article out in the Journal of Clinical Investigation identifies a new role for the enzyme CPT-1 in weight regulation; the link and a commentary are below. (all JCI commentary and articles are freely available at http://www.jci.org/ if you

A role for PWS-snoRNAs, finally!

January 17, 2006

There's a new paper out in a top journal, Science, on what is may be the first understanding of the underlying molecular basis of features of PWS - The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C --

Why is leptin ignored in obese people and animals?

January 8, 2006

As many of you know, leptin is the signal released from fat cells that relays a message to the brain that the fat cells are 'full' and it's time to stop eating. It has also been discovered that leptin works

Mighty muscles

December 13, 2005

Myostatin normally keeps muscles from growing. Scientist are trying to inhibit myostatin as a therapeutic approach for kids with muscular dystrophy; this strategy has just entered clinical trials using an antibody that sops up the myostatin. Working with Wyeth (say

Narrowing down the genetic region responsible for PWS

December 1, 2005

Below you'll find the abstract for a newly published paper trying to narrow down exactly which DNA sequences in the PW region of chromosome 15 are responsible for PWS. Here, the authors investigate a patient who meets the diagnostic criteria

Imaging 'fullness' in the brain

November 11, 2005

Another new article is just out on brain imaging during eating in people with PWS, and it better defines the changes in the brain associated with feeling full after a meal. The brain images show the lack of those changes

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