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PWS iPS cells are helping researchers make breakthroughs

May 29, 2014

One of the exciting breakthroughs in PWS research in recent years has been the development of induced pluripotent stem cells or “iPSCs”. Although there is tremendous excitement among the scientific community about iPSCs, many parents, patients, and advocates still have

The gut-brain connection: bacteria naturally carried in the gut may influence brain chemistry and behavior

March 27, 2014

Those with PWS often battle a variety of gastro-intestinal (GI) issues. Beyond general GI function and quality of life, there is a growing field of research exploring how GI composition and health is intricately connected to other systems in the

An Improved Model of PWS: Generous Donation Allows Development of an Improved Rat Model

February 15, 2014

While the genetic engineering of mouse models has allowed scientists to successfully understand and develop new therapies for many genetic diseases, the PWS mouse models generated so far have not fully mimicked the complexity of human PWS, slowing the progress

We Chose to Believe in a Bright Future for Our Son

February 12, 2014

“Happy 30th Birthday to you, Keegan Johnson, and, by the way, your son has Prader–Willi syndrome!” Although the news wasn’t delivered in song, that was essentially what was presented to Keegan and Tanya Johnson on the day they planned to

Are there benefits to testosterone replacement therapy for adult men with PWS?

October 28, 2013

One well established characteristic of PWS is altered development and function of reproductive systems. This can include hypogonadism; under-development of sexual organs, particularly the testes in males; precocious puberty; and infertility. Of these, hypogonadism, or the production of little to

Has the mystery of early puberty in PWS been solved?

June 9, 2013

Individuals with PWS typically have incomplete sexual development, but, paradoxically, often begin to exhibit signs of puberty much earlier than expected. The incidence of bone fide ‘precocious puberty’ in PWS is not entirely clear, but it is evident that normal

Replacing missing 'snoRNA' activity and restoring serotonin function with drugs

April 17, 2013

Within PWS and general obesity research, there are several labs currently working in the area of serotonin signaling. Serotonin is a neurotransmitter and this pathway contributes to the regulation of appetite and mood, and is reported to be altered in

Targeting Serotonin for PWS

April 16, 2013

In a recent email correspondence, Dr. Cunningham at the University of Texas Medical Branch thanked FPWR and described the contribution that FPWR grant funds (2010-2011) have had on the work coming out of her laboratory. She writes, "thank you for

Central adrenal insufficiency (CAI) in PWS: update on prevalence and potential effects

March 23, 2013

An FPWR blog in September 2009 highlighted research into the potential role of central adrenal insufficiency (CAI) in cases of sudden and unexpected death in PWS patients. Some recent studies provide more information on the prevalence of CAI in PWS

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