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Research (26)

PWS iPS cells are here!

September 27, 2010

Having just recently announced FPWR’s projects funded in 2010 [see full list here], it’s very exciting to already be able to announce a major advance as a result of that funding. Dr. Marc Lalande and colleagues at the University of

A Preliminary Analysis of the Phenomenology of Skin-Picking in Youth with PWS

April 28, 2010

Below is a special guest blog from Jessica Morgan, a graduate student working with Dr. Eric Storch at the University of South Florida. Their group has an interest in understanding skin picking (and other obsessive/compulsive behaviors) in PWS so that

Seizure Disorder in Prader-Willi Syndrome

July 2, 2009

Although it's rarely mentioned in clinical descriptions of PWS, anyone who hangs around families with PWS knows that seizures seem to occur much more frequently in those with PWS than typical individuals. Even in cases where a seizure disorder is

Linking Learning with Neurodevelopmental Functioning - Final Report

May 6, 2009

This project was funded by the Foundation for Prader Willi Research in 2006 and conducted by Drs. Gregory Olley and Anne Wheeler and their team at the University of North Carolina, Chapel Hill (UNC), Center for Development and Learning. Dr.

Adrenal Insufficiency and PWS

April 2, 2008

Several recent studies have begun to look more carefully at the causes of death in PWS, particularly in cases where death was sudden and/or unexpected. A review of 64 cases of death in children with PWS noted a high occurrence

An Obsessive Compulsive Mouse

February 9, 2008

Obsessive-Compulsive Disorder (OCD) affects about 2% of the population. It is characterized by persistent intrusive thoughts (obsessions), repetitive actions (compulsions), and excessive anxiety. As anyone who know someone with PWS can appreciate, OCD behaviors are very common in the PWS

Mice show the way to fix genetic disorders (updated)

May 10, 2007

It's not often that words such as "rescue of neurological deficits", "therapy for cognitive impairment," and "reversal of neurological defects" are used in the titles of papers studying genetic disorders like Angelman, Down, and Rett syndromes, but a trio of

Psychiatric illness in adults with PWS

February 5, 2007

One of the most troubling features of PWS is the high risk of mental illness in adults with the syndrome. Although a considerable amount has been written on obsessive-compulsive traits, stubbornness and maladaptive behaviors associated with PWS, less is known

Deletion vs. UPD: 70/30 or 50/50?

November 21, 2006

Most information about PWS starts out with a brief overview of the genetics of the condition. Deletion of chromosome 15 is listed as the most common cause of PWS, accounting for roughly 70% of cases. Maternal Uniparental Disomy (UPD), in

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