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Research (25)

The gut-brain connection: bacteria naturally carried in the gut may influence brain chemistry and behavior

March 27, 2014

Those with PWS often battle a variety of gastro-intestinal (GI) issues. Beyond general GI function and quality of life, there is a growing field of research exploring how GI composition and health is intricately connected to other systems in the

An Improved Model of PWS: Generous Donation Allows Development of an Improved Rat Model

February 15, 2014

While the genetic engineering of mouse models has allowed scientists to successfully understand and develop new therapies for many genetic diseases, the PWS mouse models generated so far have not fully mimicked the complexity of human PWS, slowing the progress

Are there benefits to testosterone replacement therapy in adult males with PWS?

October 28, 2013

One well established characteristic of PWS is altered development and function of reproductive systems. This can include hypogonadism; under-development of sexual organs, particularly the testes in males; precocious puberty; and infertility. Of these, hypogonadism, or the production of little to

Has the mystery of early puberty in PWS been solved?

June 9, 2013

Individuals with PWS typically have incomplete sexual development, but, paradoxically, often begin to exhibit signs of puberty much earlier than expected. The incidence of bone fide ‘precocious puberty’ in PWS is not entirely clear, but it is evident that normal

Replacing missing 'snoRNA' activity and restoring serotonin function with drugs

April 17, 2013

Within PWS and general obesity research, there are several labs currently working in the area of serotonin signaling. Serotonin is a neurotransmitter and this pathway contributes to the regulation of appetite and mood, and is reported to be altered in

Targeting serotonin for PWS

April 16, 2013

In a recent email correspondence, Dr. Cunningham at the University of Texas Medical Branch thanked FPWR and described the contribution that FPWR grant funds (2010-2011) have had on the work coming out of her laboratory. She writes, "thank you for

Central adrenal insufficiency (CAI) in PWS: update on prevalence and potential effects

March 23, 2013

An FPWR blog in September 2009 highlighted research into the potential role of central adrenal insufficiency (CAI) in cases of sudden and unexpected death in PWS patients. Some recent studies provide more information on the prevalence of CAI in PWS

Oral Health in PWS

March 23, 2013

This blog was coauthored by Jessica Bohonowych and Theresa Strong Amongst the various health issues associated with PWS, dental concerns are some of the least well studied and understood. Overall dental health can have huge impacts on susceptibility to other

More hopeful news for older individuals with neurodevelopmental disorders

April 12, 2012

Once again, there's been a signficant shift in scientific thinking about the fixed nature of brain development. The idea that the brain can't be changed after early childhood has been turned on its head in the past few years, and

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