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Research (20)

Study Explores How and Why of PWS Severity, Mosaicism In PWS By UPD

May 31, 2017

Individuals with PWS present with a very broad range of severity of symptoms, which is why people often refer to PWS as a “spectrum" disorder. A new study funded by FPWR will help us understand how and why there are

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Dr. Ingrid Tein Studies Potential Benefits of CoQ10 in PWS

May 3, 2017

Many parents of individuals with Prader-Willi syndrome (PWS) have been faced with ambiguous information about the dietary supplement coenzyme Q10 (CoQ10). There are plenty of anecdotal reports of supplemental CoQ10 providing a great improvement in metabolic function and energy levels,

Biomarkers and Beyond: 2016 Update from PWS Clinical Trials Consortium

April 27, 2017

Over the past several years, the PWS community has been fortunate to see several potential therapies for PWS enter clinical trials. To date, the only FDA-approved drug for the treatment of PWS is growth hormone, but it's clear that new

Evidence Supports Benefits of Hippotherapy

April 12, 2017

A study highlighted in Medical News Today further supports the benefits of hippotherapy with regard to behavioral tasks and cognitive development. Hippotherapy is the use of horseback riding as a therapeutic or rehabilitative treatment. The full article is available on

Bearden Research Transforming Understanding of Mental Illness in PWS

April 7, 2017

Behavior and mental health issues are an important part of Prader-Willi syndrome (PWS). In particular, one of the most challenging aspects for families to face is the onset of psychosis (i.e., mental illness characterized by symptoms, such as delusions or

Schaaf Research Connects Missing MAGEL2 Gene to PWS Symptoms

March 29, 2017

Prader Willi syndrome (PWS) results when a set of key genes on chromosome 15 are missing and/or inactive. Figuring out the role played by each of these genes in PWS is a major goal for PWS research. One of the

How to Address the Challenges of Developing PWS Therapies

March 1, 2017

Prader-Willi syndrome (PWS) is a complex disorder, and, to date, supportive care and growth hormone therapy are the only treatments available. The rarity of PWS, the fragmentation of experts and stakeholders involved at each stage of therapeutic development, and limited

Identifying the Role of the 'Hunger Hormone' Ghrelin

February 14, 2017

There are numerous hormones that are intricately involved in connecting the stomach to the brain and telling us when we are hungry or full. One of these hormones is ghrelin, which is often referred to as "the hunger hormone." Although

De-Risking PWS Drug Development Through Preclinical Screening

January 25, 2017

Any drug development process proceeds through several stages in order to produce a drug that is safe, efficacious, and has passed all regulatory requirements. Before drug candidates can be tested in humans, they need to show they are safe and

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