Author:

Falaleeva M, Welden JR, Duncan MJ, Stamm S

Scientific Notation:

Bioessays. 2017 Jun;39(6). doi: 10.1002/bies.201600264. Epub 2017 May 15.

Publication:

http://onlinelibrary.wiley.com/doi/10.1002/bies.201600264/abstract

Abstract:

C/D box snoRNAs (SNORDs) are an abundantly expressed class of short, non-coding RNAs that have been long known to perform 2′-O-methylation of rRNAs. However, approximately half of human SNORDs have no predictable rRNA targets, and numerous SNORDs have been associated with diseases that show no defects in rRNAs, among them Prader-Willi syndrome, Duplication 15q syndrome and cancer. This apparent discrepancy has been addressed by recent studies showing that SNORDs can act to regulate pre-mRNA alternative splicing, mRNA abundance, activate enzymes, and be processed into shorter ncRNAs resembling miRNAs and piRNAs. Furthermore, recent biochemical studies have shown that a given SNORD can form both methylating and non-methylating ribonucleoprotein complexes, providing an indication of the likely physical basis for such diverse new functions. Thus, SNORDs are more structurally and functionally diverse than previously thought, and their role in gene expression is under-appreciated. The action of SNORDs in non-methylating complexes can be substituted with oligonucleotides, allowing devising therapies for diseases like Prader-Willi syndrome.

KEYWORDS:

Prader-Willi syndrome; RNA methylation; RNA processing; RNA therapy; SNORD; alternative splicing; obesity; snoRNA

FPWR Grant:

The molecular mechanism of SNORD116 action and possible SNORD116 substitution strategies