Allele specific regulation of SNORD116 in PWS

Prader-Willi Syndrome (PWS), a complex genetic disorder that results from a failure to inherit a normal copy of the father’s chromosome 15. Key genes on the paternal chromosome are deleted, but how the deletion of this region leads to PWS is a complete mystery. In PWS, a normal copy of the mother’s chromosome 15 is inherited, but the genes are turned off due to what’s called genomic imprinting. This genomic imprinting is a normal process in development that turns off the maternal genes. Not much is known about the mechanisms by which the maternal chromosome is turned off in humans. The studies proposed here will provide important new information about how the region is regulated, which is a necessary step to set the stage for a better understanding of the PWS disease and, eventually, for the development of new therapeutic strategies. Our preliminary experiments in induced pluripotent stem cells derived from the skin of PWS patients suggest that there are novel mechanisms that regulate the expression of the maternal chromosome.

Research Outcomes:

Reactivation of Maternal SNORD116 Cluster via SETDB1 knockdown in Prader-Willi Syndrome iPSCs. Cruvinel E, Budinetz T, Germain N, Chamberlain S, Lalande M, Martins-Taylor K.  Human Molecular Genetics. 2014 Sep 1;23(17):4674-85.

Imprinted expression of UBE3A in non-neuronal cells from a Prader-Willi syndrome patient with an atypical deletion. Martins-Taylor K, Hsiao JS, Chen PF, Glatt-Deeley H, De Smith AJ, Blakemore AI, Lalande M, Chamberlain SJ.  Human Molecular Genetics. 2014 May 1;23(9):2364-73.

Funded Year:


Awarded to:

Kristen Martins-Taylor, PhD




Univ Connecticut

Research Outcomes:

Search Projects

Donate for PWS Research