There are two goals to this study: 1) To identify differences among individuals with PWS and autism from those who have PWS without autism by analyzing gene expression and 2) To identify new patterns of gene expression which may help explain the PWS condition or how other very small molecules that do not make protein (non-coding RNAs) implicated in this disorder are able to regulate gene expression in nerve cells. All of these studies will be done using cells found in tooth pulp (Dental Pulp Stem Cells (DPSC)) that can be collected from children who lose their “baby teeth” and donate these teeth for the study. DPSC will be grown in the laboratory and converted into nerve cells for gene expression studies. Eventually we hope to use these newly identified genes as potential therapeutic targets for the treatment of PWS, possibly using a methodology that inhibits the gene expression (RNA interference methods).
The mission of FPWR is to eliminate the challenges of Prader-Willi syndrome through the advancement of research. High-quality research will lead to more effective treatments and an eventual cure for this disorder. By working together, we intend to free our loved ones from the burdens of PWS, allowing them to lead full and independent lives.
Foundation for Prader-Willi Research Phone: 888-322-5487 Fax: 888-559-4105 Email: email@example.com